Livedoid vasculitis
Livedoid vasculitis یک بیماری پوستی مزمن است که عمدتاً در زنان جوان تا میانسال دیده می شود. یکی از مخفف‌هایی که برای توصیف ویژگی‌های آن استفاده می‌شود «زخم پورپوریک دردناک با الگوی مشبک اندام تحتانی» (PURPLE) است. این بیماری با تعدادی از بیماری ها از جمله فشار خون وریدی مزمن و واریس همراه است.
☆ در نتایج Stiftung Warentest 2022 از آلمان، رضایت مصرف کنندگان از ModelDerm فقط اندکی کمتر از مشاوره های پزشکی از راه دور بود.
می تواند با درد همراه باشد.
References
Livedoid vasculopathy یک بیماری پوستی نادر است که با زخم های دردناک مشخص می شود که به طور مداوم در قسمت پایین پاها بازمی گردد.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy یک بیماری پوستی نادر است که باعث ایجاد زخم‌های مکرر در قسمت پایین پاها می‌شود و زخم‌های کم‌رنگی به نام آتروفی بلانچ بر جای می‌گذارد. در حالی که علت دقیق آن هنوز مشخص نیست، اعتقاد بر این است که افزایش لخته شدن خون (hypercoagulability) عامل اصلی است و التهاب نقش ثانویه دارد. عوامل موثر در لخته شدن عبارتند از - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. در بیوپسی، این وضعیت لخته شدن خون در داخل رگ ها، ضخیم شدن دیواره رگ ها و زخم را نشان می دهد. درمان شامل یک رویکرد چند جانبه با تمرکز بر پیشگیری از لخته شدن خون با داروهایی مانند داروهای ضد پلاکت، رقیق‌کننده‌های خون و درمان فیبرینولیتیک است. برای این بیماری پوستی می توان از داروهای مختلفی استفاده کرد - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy یک بیماری نادر است که در آن ضایعات در هر دو پا ایجاد می شود. تصور می‌شود که تشکیل لخته‌های خون در رگ‌های خونی کوچک به دلیل افزایش لخته شدن و کاهش تجزیه لخته‌ها همراه با آسیب به پوشش رگ ایجاد می‌شود. این بیماری در زنان به خصوص در سنین 15 تا 50 سال شایع تر است. ترک سیگار، مراقبت از زخم ها و استفاده از داروهایی مانند رقیق کننده های خون و داروهای ضد پلاکت موثر بوده است.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
